2D and 3D Finite Element Simulation of the Heat Diffusion Profile of an Implantable Biomedical Device for Localized Hyperthermia

Jonas Bugase, Winston O. Soboyejo, Auphedeous Y. Dang-i

Abstract


This paper presents a 2D and 3D heat diffusion profile of a designed biomedical device for localized tumor heating and drug delivery. Hyperthermia is achieved due to the relaxation losses of the magnetic nanoparticles which are synthesized with Polydimethylsiloxane (PDMS) gel in the device. Total tumor destruction occurs when the temperature of the tumor is maintained between 41 – 46o C for a period of thirty minute or more. The heat diffusion profile of the implant and its surrounding tumor was simulated using a finite element simulation package Abaqus/CAE 6.9. In both 2D and 3D simulation where the maximum temperature was between 52oC and 55oC, the tumor temperature was maintained within the therapeutic range of 41 – 43o C for more than thirty minutes. However, for a maximum generated temperature of 45oC, the tumor temperature falls to about 39o C which is a little below the therapeutic range. The generated heat in this case is also seen to be enough to serve as the transition temperature for the thermosensitive drug loaded hydrogel embed in the device with micro channels for release since the drug release kinematic of the gel occurs between 37oC and 45oC.

Keywords


Hyperthermia; Relaxation Losses; Finite Element Simulation; Magnetic Nanoparticle

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